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PREMIUM DESIGN: With every press on the trigger, our bubble gun for kids produce a mesmerizing LED light show along with exciting sound effects giving your children hours of active fun playing time
FRUITFUL ENTERTAINMENT: With our bubble maker machine your children will have physical activity as they are outside running around chasing and popping the bubbles which will keep them healthy and fit
KIDS SAFE MATERIAL: Our bubble blower gun is made of non-toxic, sturdy, leak-resistant premium quality plastic and built-in high performance motor for automatic colored bubbles blowing in a minute
EASY TO CLEAN amp; STORE: Our bubble gun toy for kids is easy to clean and maintain. Use a wet cloth or tissues to wipe the gun and keep in a dry place. The compact size makes it easy to store the toy
PERFECT GIFT CHOICE: This bubble machine gun toy is a unique gift choice for kids to make their outdoor games a lot more enjoyable and exciting as it is small and lightweight and easy to handle
2020 Impact Factor: 9.941Submission > Acceptance: 52 days
November, 2021
No. 106 (11)
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Transducin β-like protein 1 (TBL1) plays a crucial role in controlling the stability of regulatory proteins involved in cell proliferation and autophagy induction. This study revealed that, unlike normal B cells, diffuse large B-cell lymphoma cells express abundant levels of TBL1 and its overexpression correlates with poor clinical outcome. Targeting TBL1 promoted lymphoma cell death in vitro and in vivo. These results provide the rationale for targeting TBL1 as a novel therapeutic strategy in diffuse large B-cell lymphoma.
The authors of this study developed a single-chain antibody that targets a shear gradient-specific conformation of von Willebrnad factor (VWF). In vitro studies showed that this antibody specifically reduces VWF-GPIbα binding and thrombus formation at sites of shear rate gradients but does not block platelet deposition and aggregation under constant shear rate. This characteristic places the antibody in a new class of antiplatelet therapy for selective blockade of pathological thrombus formation while maintaining normal hemostasis.
A 26-year-old female developed vaccine-induced immune thrombotic thrombocytopenia (VITT) with cerebral venous thrombosis and bi-hemispheric hemorrhage following the first dose of the ChAdOx1 nCoV-19 vaccine. The treatment protocol, based on intravenous immunoglobulins, dexamethasone and argatroban was successful with almost complete clinical, laboratory and radiological response. This experience supports the application of an early and multidisciplinary therapeutic approach in cases of VITT, with the possibility of avoiding deaths and obtain a resolution of the syndrome.
This retrospective study compared the outcome of allogeneic hematopoietic stem cell transplantation (HSCT) in 23 patients with hematologic malignancies transplanted from non-sibling fully matched related donors to that of patients who underwent conventional haplo-HSCT. Subjects transplanted from fully matched related donors showed trends to a higher relapse rate and lower cumulative incidence of grade II-IV acute graft-versus-host disease, but overall survival was similar. The authors concluded that individualized adjustment of the immunosuppressive treatment is reasonable for this category of patients.
